Publications équipes

Publications 2013

DECEMBER

At a supra-physiological concentration, human sexual hormones act as quorum-sensing inhibitors.
Beury-Cirou A, Tannières M, Minard C, Soulère L, Rasamiravaka T, Dodd RH, Queneau Y, Dessaux Y, Guillou C, Vandeputte OM, Faure D.
PLoS One. 2013 Dec 23;8(12):e83564. Partner 13

Genetics of rheumatoid arthritis contributes to biology and drug discovery.
Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieudé P, Mariette X, Louis Bridges Jr S, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantapää-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M; the RACI consortium; the GARNET consortium, Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM.
Nature. 2013 Dec 25. Partner 4

CCR1 Inhibition Ameliorates the Progression of Lupus Nephritis in NZB/W Mice.
Bignon A, Gaudin F, Hémon P, Tharinger H, Mayol K, Walzer T, Loetscher P, Peuchmaur M, Berrebi D, Balabanian K.
J Immunol. 2013 Dec 23. Partner 3

First-year radiographic progression as a predictor of further progression in early arthritis: results of a large national French cohort.
Tobón G, Saraux A, Lukas C, Gandjbakhch F, Gottenberg JE, Mariette X, Combe B, Devauchelle-Pensec V.
Arthritis Care Res (Hoboken). 2013 Dec;65(12):1907-15 Partner 4

Bacteremia in patients receiving TNF-alpha antagonists--a prospective multicenter study.
Loulergue P, Tubach F, Salmon D, Dellamonica P, Taillan B, Thorel JB, Marteau P, Bressot C, Ravaud P, Mariette X, Lortholary O; RATIO Group.
J Infect. 2013 Dec;67(6):524-8. Partner 4

Role of Fms-like tyrosine kinase 3 ligand as a potential biologic marker of lymphoma in primary Sjögren's syndrome.
Tobón GJ, Saraux A, Gottenberg JE, Quartuccio L, Fabris M, Seror R, Devauchelle-Pensec V, Morel J, Rist S, Mariette X, De Vita S, Youinou P, Pers JO.
Arthritis Rheum. 2013 Dec;65(12):3218-27. Partner 4

Endogenous retroviruses: acquisition, amplification and taming of genome invaders.
Dewannieux M, Heidmann T.
Curr Opin Virol. 2013 Dec;3(6):646-56. Partner 5

Altered skeletal muscle mitochondrial biogenesis but improved endurance capacity in trained OPA1-deficient mice.
Caffin F, Prola A, Piquereau J, Novotova M, David DJ, Garnier A, Fortin D, Alavi MV, Veksler V, Ventura-Clapier R, Joubert F.
J Physiol. 2013 Dec 1;591(Pt 23):6017-37. Partner 2

Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjogren's syndrome.
Nocturne G, Boudaoud S, Miceli-Richard C, Viengchareun S, Lazure T, Nititham J, Taylor KE, Ma A, Busato F, Melki J, Lessard CJ, Sivils KL, Dubost JJ, Hachulla E, Gottenberg JE, Lombès M, Tost J, Criswell LA, Mariette X.
Blood. 2013 Dec 12;122(25):4068-76. Partner 4

In Vitro Selection of Modified RNA Aptamers Against CD44 Cancer Stem Cell Marker.
Ababneh N, Alshaer W, Allozi O, Mahafzah A, El-Khateeb M, Hillaireau H, Noiray M, Fattal E, Ismail S.
Nucleic Acid Ther. 2013 Dec;23(6):401-7. Partner 16

Hypervalent iodine-mediated oxidative cyclisation of p-hydroxy acetanilides to 1,2-dispirodienones.
Chabaud L, Hromjakova T, Rambla M, Retailleau P, Guillou C.
Chem Commun (Camb). 2013 Dec 21;49(98):11542-4. Partner 13

Development of DANDYs, New 3,5-Diaryl-7-azaindoles Demonstrating Potent DYRK1A Kinase Inhibitory Activity.
Gourdain S, Dairou J, Denhez C, Bui LC, Rodrigues-Lima F, Janel N, Delabar JM, Cariou K, Dodd RH.
J Med Chem. 2013 Dec 12;56(23):9569-85. Partner 13

α- and β-hydrazino acid-based pseudopeptides inhibit the chymotrypsin-like activity of the eukaryotic 20S proteasome.
Bordessa A, Keita M, Maréchal X, Formicola L, Lagarde N, Rodrigo J, Bernadat G, Bauvais C, Soulier JL, Dufau L, Milcent T, Crousse B, Reboud-Ravaux M, Ongeri S.
Eur J Med Chem. 2013 Dec;70:505-24. Partner 15

Discovery and hit to lead optimization of novel combretastatin a-4 analogues: dependence of C-linker length and hybridization.
Provot O, Hamze A, Peyrat JF, Brion JD, Alami M.
Anticancer Agents Med Chem. 2013 Dec;13(10):1614-35. Partner 15

Targeting the splicing of mRNA in autoimmune diseases: BAFF inhibition in Sjögren's syndrome as a proof of concept.
Roescher N, Vosters JL, Al Saleh G, Dreyfus P, Jacques S, Chiocchia G, Sibilia J, Tak PP, Chiorini JA, Mariette X, Gottenberg JE.
Mol Ther. 2013 Dec 5. Partner 4

Riociguat for pulmonary hypertension.
Ghofrani HA, Simonneau G, Rubin LJ; Authors of CHEST-1 and PATENT-1.
N Engl J Med. 2013 Dec 5;369(23):2268. Partner 6

Pathogenesis of pulmonary arterial hypertension: lessons from cancer.
Guignabert C, Tu L, Le Hiress M, Ricard N, Sattler C, Seferian A, Huertas A, Humbert M, Montani D.
Eur Respir Rev. 2013 Dec 1;22(130):543-51. Partner 6

New perspectives in long-term outcomes in clinical trials of pulmonary arterial hypertension.
Preston IR, Suissa S, Humbert M.
Eur Respir Rev. 2013 Dec 1;22(130):495-502. Partner 6

The need to move from 6-minute walk distance to outcome trials in pulmonary arterial hypertension.
Gaine S, Simonneau G.
Eur Respir Rev. 2013 Dec 1;22(130):487-94. Partner 6

A paradigm shift in pulmonary arterial hypertension management.
Rubin LJ, Galiè N, Simonneau G, McLaughlin V.
Eur Respir Rev. 2013 Dec 1;22(130):423-6. Partner 6

Poly(ethylene glycol) methacrylate hydrolyzable microspheres for transient vascular embolization.
Louguet S, Verret V, Bédouet L, Servais E, Pascale F, Wassef M, Labarre D, Laurent A, Moine L.
Acta Biomater. 2013 Dec 7. pii: S1742-7061(13)00595-3. Partner 16

Pulmonary arterial hypertension: epidemiology and registries.
McGoon MD, Benza RL, Escribano-Subias P, Jiang X, Miller DP, Peacock AJ, Pepke-Zaba J, Pulido T, Rich S, Rosenkranz S, Suissa S, Humbert M.
J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D51-9. Partner 6

Updated clinical classification of pulmonary hypertension.
Simonneau G, Gatzoulis MA, Adatia I, Celermajer D, Denton C, Ghofrani A, Gomez Sanchez MA, Krishna Kumar R, Landzberg M, Machado RF, Olschewski H, Robbins IM, Souza R.
J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D34-41. Partner 6

Genetics and genomics of pulmonary arterial hypertension.
Soubrier F, Chung WK, Machado R, Grünig E, Aldred M, Geraci M, Loyd JE, Elliott CG, Trembath RC, Newman JH, Humbert M.
J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D13-21. Partner 6

Pulmonary hypertension in chronic lung diseases.
Seeger W, Adir Y, Barberà JA, Champion H, Coghlan JG, Cottin V, De Marco T, Galiè N, Ghio S, Gibbs S, Martinez FJ, Semigran MJ, Simonneau G, Wells AU, Vachiéry JL.
J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D109-16. Partner 6

Pulmonary hypertension due to left heart diseases.
Vachiéry JL, Adir Y, Barberà JA, Champion H, Coghlan JG, Cottin V, De Marco T, Galiè N, Ghio S, Gibbs JS, Martinez F, Semigran M, Simonneau G, Wells A, Seeger W.
J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D100-8. Partner 6

The fifth world symposium on pulmonary hypertension.
Galiè N, Simonneau G.
J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D1-3. Partner 6

Efficacy and safety of belimumab in primary Sjogren's syndrome: results of the BELISS open-label phase II study.
Mariette X, Seror R, Quartuccio L, Baron G, Salvin S, Fabris M, Desmoulins F, Nocturne G, Ravaud P, De Vita S.
Ann Rheum Dis. 2013 Dec 17. Partner 4

A microdevice for parallelized pulmonary permeability studies.
Bol L, Galas JC, Hillaireau H, Le Potier I, Nicolas V, Haghiri-Gosnet AM, Fattal E, Taverna M.
Biomed Microdevices. 2013 Dec 17. Partner 16

Evidence for the Involvement of Type I Interferon in Pulmonary Arterial Hypertension.
George PM, Oliver E, Dorfmüller P, Dubois OD, Reed DM, Kirkby NS, Mohamed NA, Perros F, Antigny F, Fadel E, Schreiber BE, Holmes A, Southwood M, Hagan G, Wort SJ, Bartlett N, Morrell NW, Coghlan G, Humbert M, Zhao L, Mitchell JA.
Circ Res. 2013 Dec 13. Partner 6

Immunotherapies and targeted therapies in medical oncology.
Rousseau B, Champiat S, Loirat D, Arrondeau J, Lemoine N, Soria JC.
Bull Cancer. 2013 Dec 12. Partner 9

RGD decoration of PEGylated polyester nanocapsules of perfluorooctyl bromide for tumor imaging: Influence of pre or post-functionalization on capsule morphology.
Diou O, Fattal E, Delplace V, Mackiewicz N, Nicolas J, Mériaux S, Valette J, Robic C, Tsapis N.
Eur J Pharm Biopharm. 2013 Dec 11. pii: S0939-6411(13)00385-8. Partner 16

Relevant issues in the pathology and pathobiology of pulmonary hypertension.
Tuder RM, Archer SL, Dorfmüller P, Erzurum SC, Guignabert C, Michelakis E, Rabinovitch M, Schermuly R, Stenmark KR, Morrell NW.
J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D4-D12. Partner 6

NOVEMBER

A one-pot synthesis of 3-trifluoromethyl-2-isoxazolines from trifluoromethyl aldoxime.
Gonçalves RS, Dos Santos M, Bernadat G, Bonnet-Delpon D, Crousse B.
Beilstein J Org Chem. 2013 Nov 7;9:2387-94. Partner 15

Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain.
Stura EA, Visse R, Cuniasse P, Dive V, Nagase H.
FASEB J. 2013 Nov;27(11):4395-405. Partner 11

Differential regulation of cardiac excitation-contraction coupling by cAMP phosphodiesterase subtypes.
Mika D, Bobin P, Pomérance M, Lechêne P, Westenbroek RE, Catterall WA, Vandecasteele G, Leroy J, Fischmeister R.
Cardiovasc Res. 2013 Nov 1;100(2):336-46. Partner 2

A high-throughput screen identifies PARP1/2 inhibitors as a potential therapy for ERCC1-deficient non-small cell lung cancer.
Postel-Vinay S, Bajrami I, Friboulet L, Elliott R, Fontebasso Y, Dorvault N, Olaussen KA, André F, Soria JC, Lord CJ, Ashworth A.
Oncogene. 2013 Nov 21;32(47):5377-87. Partner 9

Unexpected toxicity of cetuximab combined with conventional chemoradiotherapy in patients with locally advanced anal cancer: results of the UNICANCER ACCORD 16 phase II trial.
Deutsch E, Lemanski C, Pignon JP, Levy A, Delarochefordiere A, Martel-Lafay I, Rio E, Malka D, Conroy T, Miglianico L, Becouarn Y, Malekzadeh K, Paris E, Juzyna B, Ezra P, Azria D.
Ann Oncol. 2013 Nov;24(11):2834-8.. Partner 8

Palladium(II)-catalyzed oxidative arylation of quinoxalin-2(1H)-ones with arylboronic acids.
Carrër A, Brion JD, Messaoudi S, Alami M.
Org Lett. 2013 Nov 1;15(21):5606-9. Partner 15

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.
Lessard CJ, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM, Kelly JA, Dozmorov MG, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta ML, Brun JG, Gøransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnström M, Jazebi H, Cunninghame Graham DS, Grandits ME, Nazmul-Hossain AN, Patel K, Adler AJ, Maier-Moore JS, Farris AD, Brennan MT, Lessard JA, Chodosh J, Gopalakrishnan R, Hefner KS, Houston GD, Huang AJ, Hughes PJ, Lewis DM, Radfar L, Rohrer MD, Stone DU, Wren JD, Vyse TJ, Gaffney PM, James JA, Omdal R, Wahren-Herlenius M, Illei GG, Witte T, Jonsson R, Rischmueller M, Rönnblom L, Nordmark G, Ng WF; UK Primary Sjögren's Syndrome Registry, Mariette X, Anaya JM, Rhodus NL, Segal BM, Scofield RH, Montgomery CG, Harley JB, Sivils KL.
Nat Genet. 2013 Nov;45(11):1284-92. Partner 4

New strategies to overcome resistance to mammalian target of rapamycin inhibitors in breast cancer.
Vicier C, Dieci MV, Andre F.
Curr Opin Oncol. 2013 Nov;25(6):587-93. Partner 9

Issues in clinical research for metastatic breast cancer.
Dogan S, Andre F, Arnedos M.
Curr Opin Oncol. 2013 Nov;25(6):625-9. Partner 9

Dual Targeting of HER2-Positive Cancer with Trastuzumab Emtansine and Pertuzumab: Critical Role for Neuregulin Blockade in Antitumor Response to Combination Therapy.
Phillips GD, Fields CT, Li G, Dowbenko D, Schaefer G, Miller K, Andre F, Burris HA 3rd, Albain KS, Harbeck N, Dieras V, Crivellari D, Fang L, Guardino E, Olsen SR, Crocker LM, Sliwkowski MX.
Clin Cancer Res. 2013 Nov 22. Partner 9

Nickel-catalyzed arylation, alkenylation, and alkynylation of unprotected thioglycosides at room temperature.
Brachet E, Brion JD, Alami M, Messaoudi S.
Chemistry. 2013 Nov 4;19(45):15276-80. Partner 15

On the characterization of the surface chemistry of quantum dots.
Knittel F, Gravel E, Cassette E, Pons T, Pillon F, Dubertret B, Doris E.
Nano Lett. 2013 Nov 13;13(11):5075-8. Partner 12

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update.
Smolen JS, Landewé R, Breedveld FC, Buch M, Burmester G, Dougados M, Emery P, Gaujoux-Viala C, Gossec L, Nam J, Ramiro S, Winthrop K, de Wit M, Aletaha D, Betteridge N, Bijlsma JW, Boers M, Buttgereit F, Combe B, Cutolo M, Damjanov N, Hazes JM, Kouloumas M, Kvien TK, Mariette X, Pavelka K, van Riel PL, Rubbert-Roth A, Scholte-Voshaar M, Scott DL, Sokka-Isler T, Wong JB, van der Heijde D.
Ann Rheum Dis. 2013 Oct 25. Partner 4

Proinflammatory cytokine levels are linked with death in pulmonary arterial hypertension.
Cracowski JL, Chabot F, Labarère J, Faure P, Degano B, Schwebel C, Chaouat A, Reynaud-Gaubert M, Cracowski C, Sitbon O, Yaici A, Simonneau G, Humbert M.
Eur Respir J. 2013 Nov 14. Partner 6

International Union of Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors.
Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, Mantovani A, Matsushima K, Murphy PM, Nibbs R, Nomiyama H, Power CA, Proudfoot AE, Rosenkilde MM, Rot A, Sozzani S, Thelen M, Yoshie O, Zlotnik A.
Pharmacol Rev. 2013 Nov 11;66(1):1-79. Partner 3

Semisynthesis of Macrocarpal C and Analogues by Selective Dehydration of Macrocarpal A or B.
Alliot J, Gravel E, Larquetoux L, Nicolas M, Doris E.
J Nat Prod. 2013 Nov 21. Partner 12

In vivo imaging of matrix metalloprotease 12 and matrix metalloprotease 13 activities in the mouse model of collagen-induced arthritis.
Lim NH, Meinjohanns E, Bou-Gharios G, Gompels LL, Nuti E, Rossello A, Devel L, Dive V, Meldal M, Nagase H.
Arthritis Rheum. 2013 Nov 27. Partner 11

MiR-210: A potential therapeutic target against radiation-induced enteropathy.
Hamama S, Noman MZ, Gervaz P, Delanian S, Vozenin MC.
Radiother Oncol. 2013 Nov 26. pii: S0167-8140(13)00539-2. Partner 8

Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme.
Masuyer G, Akif M, Czarny B, Beau F, Schwager SL, Sturrock ED, Isaac RE, Dive V, Acharya KR.
FEBS J. 2013 Nov 29. Partner 11

Bone morphogenetic proteins protect pulmonary microvascular endothelial cells from apoptosis by upregulating α-B-crystallin.
Ciumas M, Eyries M, Poirier O, Maugenre S, Dierick F, Gambaryan N, Montagne K, Nadaud S, Soubrier F.
Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2577-84. Partner 6

OCTOBER

Physical and virtual screening methods for marine toxins and drug discovery targeting nicotinic acetylcholine receptors.
Molgó J, Aráoz R, Benoit E, Iorga BI.
Expert Opin Drug Discov. 2013 Oct;8(10):1203-23. Partner 13

Five-year favorable outcome of patients with early rheumatoid arthritis in the 2000s: data from the ESPOIR cohort.
Combe B, Rincheval N, Benessiano J, Berenbaum F, Cantagrel A, Daurès JP, Dougados M, Fardellone P, Fautrel B, Flipo RM, Goupille P, Guillemin F, Le Loët X, Logeart I, Mariette X, Meyer O, Ravaud P, Saraux A, Schaeverbeke T, Sibilia J.
J Rheumatol. 2013 Oct;40(10):1650-7. Partner 4

Calixarene cleansing formulation for uranium skin contamination.
Phan G, Semili N, Bouvier-Capely C, Landon G, Mekhloufi G, Huang N, Rebière F, Agarande M, Fattal E.
Health Phys. 2013 Oct;105(4):382-9. Partner 16

Spontaneous formation of nitrarine and polycyclic skeletons related to Nitraria indolic alkaloids under non-enzymic conditions.
Gravel E, Harfouche A, Salame R, Leblanc K, Maciuk A, Poupon E.
Chemistry. 2013 Oct 18;19(43):14515-20. Partner 12&15

Tyrosine kinase inhibitors in pulmonary arterial hypertension: a double-edge sword?
Godinas L, Guignabert C, Seferian A, Perros F, Bergot E, Sibille Y, Humbert M, Montani D.
Semin Respir Crit Care Med. 2013 Oct;34(5):714-24.Partner 6

Inflammatory mechanisms in HIV-associated pulmonary arterial hypertension.
Tcherakian C, Couderc LJ, Humbert M, Godot V, Sitbon O, Devillier P.
Semin Respir Crit Care Med. 2013 Oct;34(5):645-53. Partner 6

Idiopathic pulmonary arterial hypertension.
Souza R, Jardim C, Humbert M.
Semin Respir Crit Care Med. 2013 Oct;34(5):560-7.Partner 6

Current challenges in pulmonary hypertension.
Humbert M.
Semin Respir Crit Care Med. 2013 Oct;34(5):549-50. Partner 6

ERCC1 function in nuclear excision and interstrand crosslink repair pathways is mediated exclusively by the ERCC1-202 isoform.
Friboulet L, Postel-Vinay S, Sourisseau T, Adam J, Stoclin A, Ponsonnailles F, Dorvault N, Commo F, Saulnier P, Salome-Desmoulez S, Pottier G, André F, Kroemer G, Soria JC, Olaussen KA.
Cell Cycle. 2013 Oct 15;12(20):3298-306. Partner 9

Pathology and pathobiology of pulmonary hypertension.
Guignabert C, Dorfmuller P.
Semin Respir Crit Care Med. 2013 Oct;34(5):551-9. Partner 6

Right ventricular diastolic impairment in patients with pulmonary arterial hypertension.
Rain S, Handoko ML, Trip P, Gan CT, Westerhof N, Stienen GJ, Paulus WJ, Ottenheijm CA, Marcus JT, Dorfmüller P, Guignabert C, Humbert M, Macdonald P, Dos Remedios C, Postmus PE, Saripalli C, Hidalgo CG, Granzier HL, Vonk-Noordegraaf A, van der Velden J, de Man FS.
Circulation. 2013 Oct 29;128(18):2016-25, 1-10. Partner 6

Update on the safety profile of certolizumab pegol in rheumatoid arthritis: an integrated analysis from clinical trials.
Bykerk VP, Cush J, Winthrop K, Calabrese L, Lortholary O, de Longueville M, van Vollenhoven R, Mariette X.
Ann Rheum Dis. 2013 Oct 3. Partner 4

Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow.
Devi S, Wang Y, Chew WK, Lima R, A-González N, Mattar CN, Chong SZ, Schlitzer A, Bakocevic N, Chew S, Keeble JL, Goh CC, Li JL, Evrard M, Malleret B, Larbi A, Renia L, Haniffa M, Tan SM, Chan JK, Balabanian K, Nagasawa T, Bachelerie F, Hidalgo A, Ginhoux F, Kubes P, Ng LG.
J Exp Med. 2013 Oct 21;210(11):2321-36. Partner 3

Emerging Molecular Targets for Anti-proliferative Strategies in Pulmonary Arterial Hypertension.
Tu L, Guignabert C.
Handb Exp Pharmacol. 2013;218:409-36. Partner 6

Definition and classification of pulmonary hypertension.
Humbert M, Montani D, Evgenov OV, Simonneau G.
Handb Exp Pharmacol. 2013;218:3-29. Partner 6

Inactivation of the Carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase: a study using genetically encoded FRET-based reporters.
Cazabat L, Ragazzon B, Varin A, Potier-Cartereau M, Vandier C, Vezzosi D, Risk-Rabin M, Guellich A, Schittl J, Lechêne P, Richter W, Nikolaev VO, Zhang J, Bertherat J, Vandecasteele G.
Hum Mol Genet. 2013 Oct 22. Partner 2

Nuclear factor κ-B is activated in the pulmonary vessels of patients with end-stage idiopathic pulmonary arterial hypertension.
Price LC, Caramori G, Perros F, Meng C, Gambaryan N, Dorfmuller P, Montani D, Casolari P, Zhu J, Dimopoulos K, Shao D, Girerd B, Mumby S, Proudfoot A, Griffiths M, Papi A, Humbert M, Adcock IM, Wort SJ.
PLoS One. 2013 Oct 4;8(10):e75415. Partner 6

Pulmonary arterial hypertension in familial hemiplegic migraine with ATP1A2 channelopathy.
Montani D, Girerd B, Günther S, Riant F, Tournier-Lasserve E, Magy L, Maazi N, Guignabert C, Savale L, Sitbon O, Simonneau G, Soubrier F, Humbert M.
Eur Respir J. 2013 Oct 17. Partner 6

The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1).
Courilleau D, Bouyssou P, Fischmeister R, Lezoualc'h F, Blondeau JP.
Biochem Biophys Res Commun. 2013 Oct 25;440(3):443-8. Partner 2

Disturbed adiponectin - AMPK system in skeletal muscle of patients with metabolic syndrome.
Berendoncks AM, Stensvold D, Garnier A, Fortin D, Sente T, Vrints CJ, Arild SS, Ventura-Clapier R, Wisløff U, Conraads VM.
Eur J Prev Cardiol. 2013 Oct 8. Partner 2

The beneficial effect of suramin on monocrotaline-induced pulmonary hypertension in rats.
Izikki M, Mercier O, Lecerf F, Guin LL, Hoang E, Dorfmüller P, Perros F, Humbert M, Simonneau G, Dartevelle P, Fadel E, Eddahibi S.
PLoS One. 2013 Oct 15;8(10):e77073. Partner 6

Toll-like receptor induced pro-interleukin-1β and interleukin-6 in monocytes are lower in healthy infants compared to adults.
Libraty DH, Zhang L, Woda M, Acosta LP, Obcena A, Brion JD, Capeding RZ.
PLoS One. 2013 Oct 25;8(10):e78018. Partner 15

Right ventricular plasticity in a porcine model of chronic pressure overload.
Guihaire J, Haddad F, Boulate D, Capderou A, Decante B, Flécher E, Eddahibi S, Dorfmüller P, Hervé P, Humbert M, Verhoye JP, Dartevelle P, Mercier O, Fadel E.
J Heart Lung Transplant. 2013 Oct 25. pii: S1053-2498(13)01507-6. Partner 6

Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.
Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev VO, Vandecasteele G, Fischmeister R, El-Armouche A.
J Am Coll Cardiol. 2013 Oct 22;62(17):1596-606. Partner 2

SEPTEMBER

Synthesis and antiprotozoal activity of original porphyrin precursors and derivatives.
Abada Z, Cojean S, Pomel S, Ferrié L, Akagah B, Lormier AT, Loiseau PM, Figadère B.
Eur J Med Chem. 2013 Sep;67:158-65. Partner 15

Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp.
Coulerie P, Nour M, Maciuk A, Eydoux C, Guillemot JC, Lebouvier N, Hnawia E, Leblanc K, Lewin G, Canard B, Figadère B.
Planta Med. 2013 Sep;79(14):1313-8. Partner 15

Stereoselective copper-catalyzed Chan-Lam-Evans N-arylation of glucosamines with arylboronic acids at room temperature.
Bruneau A, Brion JD, Alami M, Messaoudi S.
Chem Commun (Camb). 2013 Sep 28;49(75):8359-61. Partner 15

Strategies for the design of orally bioavailable antileishmanial treatments.
Pham TT, Loiseau PM, Barratt G.
Int J Pharm. 2013 Sep 15;454(1):539-52. Partner 15&16

Pharmacokinetic evaluation of sildenafil as a pulmonary hypertension treatment.
Chaumais MC, Perrin S, Sitbon O, Simonneau G, Humbert M, Montani D.
Expert Opin Drug Metab Toxicol. 2013 Sep;9(9):1193-205. Partner 6

Editorial: Pannexin-1--the hidden gatekeeper for HIV-1.
Paoletti A, Raza SQ, Voisin L, Law F, Caillet M, Martins I, Deutsch E, Perfettini JL.
J Leukoc Biol. 2013 Sep;94(3):390-2. Partner 8

Complications of thoracic radiotherapy.
Chargari C, Riet F, Mazevet M, Morel E, Lepechoux C, Deutsch E.
Presse Med. 2013 Sep;42(9 Pt 2):e342-51. Review Partner 2&8

Complications of chemotherapy, a basic science update.
Mazevet M, Moulin M, Llach-Martinez A, Chargari C, Deutsch E, Gomez AM, Morel E.
Presse Med. 2013 Sep;42(9 Pt 2):e352-61. Review Partner 2&8

Drugs induced pulmonary arterial hypertension.
Seferian A, Chaumais MC, Savale L, Günther S, Tubert-Bitter P, Humbert M, Montani D.
Presse Med. 2013 Sep;42(9 Pt 2):e303-10. Partner 6

Thorax Innovation (TORINO).
Humbert M.
Presse Med. 2013 Sep;42(9 Pt 2):e301-2. Partner 6

Anti-interleukin-5 therapy in severe asthma.
Garcia G, Taillé C, Laveneziana P, Bourdin A, Chanez P, Humbert M.
Eur Respir Rev. 2013 Sep 1;22(129):251-7. Partner 6

Drug-induced pulmonary arterial hypertension: a recent outbreak.
Montani D, Seferian A, Savale L, Simonneau G, Humbert M.
Eur Respir Rev. 2013 Sep 1;22(129):244-50. Partner 6

Therapies for pulmonary arterial hypertension: where are we today, where do we go tomorrow?
Seferian A, Simonneau G.
Eur Respir Rev. 2013 Sep 1;22(129):217-26. Partner 6

Diffusion capacity and BMPR2 mutations in pulmonary arterial hypertension.
Trip P, Girerd B, Bogaard HJ, de Man FS, Boonstra A, Garcia G, Humbert M, Montani D, Vonk-Noordegraaf A.
Eur Respir J. 2013 Sep 13. Partner 6

A proof of concept for the detection and classification of pulmonary arterial hypertension through breath analysis with a sensor array.
Cohen-Kaminsky S, Nakhleh M, Perros F, Montani D, Girerd B, Garcia G, Simonneau G, Haick H, Humbert M.
Am J Respir Crit Care Med. 2013 Sep 15;188(6):756-9. Partner 6

Development of a Usutu virus specific real-time reverse transcription PCR assay based on sequenced strains from Africa and Europe.
Nikolay B, Weidmann M, Dupressoir A, Faye O, Boye CS, Diallo M, Sall AA.
J Virol Methods. 2013 Sep 12. Partner 5

Csp2-N bond formation via ligand-free Pd-catalyzed oxidative coupling reaction of N-tosylhydrazones and indole derivatives.
Roche M, Frison G, Brion JD, Provot O, Hamze A, Alami M.
J Org Chem. 2013 Sep 6;78(17):8485-95. Partner 15

AUGUST

Paleovirology of 'syncytins', retroviral env genes exapted for a role in placentation.
Lavialle C, Cornelis G, Dupressoir A, Esnault C, Heidmann O, Vernochet C, Heidmann T.
Philos Trans R Soc Lond B Biol Sci. 2013 Aug 12;368(1626):20120507. Partner 5

Macitentan and morbidity and mortality in pulmonary arterial hypertension.
Pulido T, Adzerikho I, Channick RN, Delcroix M, Galiè N, Ghofrani HA, Jansa P, Jing ZC, Le Brun FO, Mehta S, Mittelholzer CM, Perchenet L, Sastry BK, Sitbon O, Souza R, Torbicki A, Zeng X, Rubin LJ, Simonneau G; SERAPHIN Investigators.
N Engl J Med. 2013 Aug 29;369(9):809-18. Partner 6

Epidemiology of primary Sjögren's syndrome in a French Multi-Racial/Ethnic area.
Maldini C, Seror R, Fain O, Dhote R, Amoura Z, De Bandt M, Delassus JL, Falgarone G, Guillevin L, Le Guern V, Lhote F, Meyer O, Ramanoelina J, Sacré K, Uzunhan Y, Leroux JL, Mariette X, Mahr A.
Arthritis Care Res (Hoboken). 2013 Aug 27. Partner 4

Quantification of residual risk of relapse in breast cancer patients optimally treated.
Dieci MV, Arnedos M, Delaloge S, Andre F.
Breast. 2013 Aug;22 Suppl 2:S92-5. Partner 9

JULY

Pulmonary drug delivery: from generating aerosols to overcoming biological barriers-therapeutic possibilities and technological challenges.
Ruge CA, Kirch J, Lehr CM.
Lancet Respir Med. 2013 Jul;1(5):402-13. Partner 16

Discovery of two new inhibitors of Botrytis cinerea chitin synthase by a chemical library screening.
Magellan H, Boccara M, Drujon T, Soulié MC, Guillou C, Dubois J, Becker HF.
Bioorg Med Chem. 2013 Jul 2. Partner 13

NCR3/NKp30 Contributes to Pathogenesis in Primary Sjogren's Syndrome.
Rusakiewicz S, Nocturne G, Lazure T, Semeraro M, Flament C, Caillat-Zucman S, Sène D, Delahaye N, Vivier E, Chaba K, Poirier-Colame V, Nordmark G, Eloranta ML, Eriksson P, Theander E, Forsblad-d'Elia H, Omdal R, Wahren-Herlenius M, Jonsson R, Rönnblom L, Nititham J, Taylor KE, Lessard CJ, Sivils KL, Gottenberg JE, Criswell LA, Miceli-Richard C, Zitvogel L, Mariette X.
Sci Transl Med. 2013 Jul 24;5(195):195ra96. Partner 4

A novel channelopathy in pulmonary arterial hypertension.
Ma L, Roman-Campos D, Austin ED, Eyries M, Sampson KS, Soubrier F, Germain M, Trégouët DA, Borczuk A, Rosenzweig EB, Girerd B, Montani D, Humbert M, Loyd JE, Kass RS, Chung WK.
N Engl J Med. 2013 Jul 25;369(4):351-61. Partner 6

Riociguat for the treatment of pulmonary arterial hypertension.
Ghofrani HA, Galiè N, Grimminger F, Grünig E, Humbert M, Jing ZC, Keogh AM, Langleben D, Kilama MO, Fritsch A, Neuser D, Rubin LJ; PATENT-1 Study Group.
N Engl J Med. 2013 Jul 25;369(4):330-40. Partner 6

Riociguat for the treatment of chronic thromboembolic pulmonary hypertension.
Ghofrani HA, D'Armini AM, Grimminger F, Hoeper MM, Jansa P, Kim NH, Mayer E, Simonneau G, Wilkins MR, Fritsch A, Neuser D, Weimann G, Wang C; CHEST-1 Study Group.
N Engl J Med. 2013 Jul 25;369(4):319-29. Partner 6

Role of cyclic nucleotide phosphodiesterases type 3 and 4 in cardiac excitation-contraction coupling and arrhythmias
Mika D, Leroy J, Fischmeister R, Vandecasteele G.
Med Sci (Paris). 2013 Jun-Jul;29(6-7):617-22. French Partner 2

Pulmonary arterial hypertension: a flavor of autoimmunity.
Perros F, Humbert M, Cohen-Kaminsky S.
Med Sci (Paris). 2013 6-7;29(6-7):607-616. Epub 2013 Jul 12. French. Partner 6

Advances in understanding the pathogenesis of primary Sjögren's syndrome.
Nocturne G, Mariette X.
Nat Rev Rheumatol. 2013 Jul 16. Partner 4

J Mol Recognit. 2013 Jul;26(7):318-29. Partner 16
siRNA associated with immunonanoparticles directed against cd99 antigen improves gene expression inhibition in vivo in Ewing's sarcoma.
Ramon AL, Bertrand JR, de Martimprey H, Bernard G, Ponchel G, Malvy C, Vauthier C.
Link

Anticancer Drugs. 2013 Jul;24(6):599-608. Partner 8
The combination of the antiviral agent cidofovir and anti-EGFR antibody cetuximab exerts an antiproliferative effect on HPV-positive cervical cancer cell lines' in-vitro and in-vivo xenografts.
Deberne M, Levy A, Mondini M, Dessen P, Vivet S, Supiramaniam A, Vozenin MC, Deutsch E.
Link

JUNE

An efficient coupling of N-tosylhydrazones with 2-halopyridines: synthesis of 2-α-styrylpyridines endowed with antitumor activity.
Lawson M, Hamze A, Peyrat JF, Bignon J, Dubois J, Brion JD, Alami M.
Org Biomol Chem. 2013 Jun 14;11(22):3664-73. Partner 15

Org Lett. 2013 Jun 7;15(11):2866-8. Partner 12
Synthesis of a functionalizable water-soluble cryptophane-111.
Dubost E, Kotera N, Garcia-Argote S, Boulard Y, Léonce E, Boutin C, Berthault P, Dugave C, Rousseau B.
Link

Chest. 2013 Jun 6. Partner 4
Incidence and risk factors of Legionella pneumophila pneumonia during anti-TNF therapy: a prospective French study.
Lanternier F, Tubach F, Ravaud P, Salmon D, Dellamonica P, Bretagne S, Couret M, Bouvard B, Debandt M, Gueit I, Gendre JP, Leone J, Nicolas N, Che D, Mariette X, Lortholary O.
Link

Arthritis Rheum. 2013 Jun 5. [Epub ahead of print] Partner 6
Survival and prognostic factors in systemic sclerosis-associated pulmonary hypertension: A systematic review and meta-analysis.
Lefèvre G, Dauchet L, Hachulla E, Montani D, Sobanski V, Lambert M, Hatron PY, Humbert M, Launay D.
Link

Arthritis Rheum. 2013 Jun 5. [Epub ahead of print] Partner 4
CCL19, a B-cell chemokine, is related to the decrease of blood memory B-cells and predicts the clinical response to rituximab in rheumatoid arthritis.
Sellam J, Rouanet S, Hendel-Chavez H, Miceli-Richard C, Combe B, Sibilia J, Le Loët X, Tebib J, Jourdan R, Dougados M, Taoufik Y, Mariette X.
Link

Int J Pharm. 2013 Jun 6. [Epub ahead of print] Partner 3 & Partner 16
Toxicity of surface-modified PLGA nanoparticles toward lung alveolar epithelial cells.
Grabowski N, Hillaireau H, Vergnaud J, Aragao LS, Kerdine-Romer S, Pallardy M, Tsapis N, Fattal E.
Link

Arthritis Care Res (Hoboken). 2013 Jun 10. [Epub ahead of print] Partner 4
Safety of surgery after rituximab therapy in 133 patients with rheumatoid arthritis: Data from the AutoImmunity and Rituximab registry.
Godot S, Gottenberg JE, Paternotte S, Pane I, Combe B, Sibilia J, Flipo RM, Schaeverbeke T, Ravaud P, Toussirot E, Berenbaum F, Mariette X, Wendling D, Sellam J.
Link

Chemistry. 2013 Jun 10. [Epub ahead of print] Partner 13
Fast Synthesis of Complex Enantiopure Heterocyclic Scaffolds by a Tandem Sequence of Simple Transformations on α-Hydroxyaldehydes.
Cannillo A, Norsikian S, Retailleau P, Dau ME, Iorga BI, Beau JM.
Link

Nanoscale. 2013 Jun 10. [Epub ahead of print] Partner 12
Carbon nanotube-gold nanohybrids for selective catalytic oxidation of alcohols.
Kumar R, Gravel E, Hagège A, Li H, Jawale DV, Verma D, Namboothiri IN, Doris E.
Link

Allergy. 2013 Jun 10. [Epub ahead of print] Partner 3, Partner 11 & Partner 15
Identification and frequency of circulating CD4+ T lymphocytes specific to Benzylpenicillin in healthy donors.
Nhim C, Delluc S, Halgand F, de Chaisemartin L, Weaver RJ, Claude N, Joseph D, Maillère B, Pallardy M.
Link

J Immunotoxicol. 2013 Jun 7. [Epub ahead of print] Partner 3
Immunomodulation and lymphoma in humans.
Ponce RA, Gelzleichter T, Haggerty HG, Heidel S, Holdren MS, Lebrec H, Mellon RD, Pallardy M.
Link

Expert Opinion on Drug Metabolism & Toxicology. 2013 Jun 12 Partner 6
Pharmacokinetic evaluation of sildenafil as a pulmonary hypertension treatment.
Marie-Camille Chaumais, Swanny Perrin, Olivier Sitbon, Gérald Simonneau, Marc Humbert, David Montani
Link

Eur J Med Chem 2013 Jun 12 Partner 15
Synthesis and antiprotozoal activity of original porphyrin precursors and derivatives.
Zahra Abada, Sandrine Cojean, Sébastien Pomel, Laurent Ferrié, Bernardin Akagah, Anh Tuan Lormier, Philippe M. Loiseau, Bruno Figadere
Link

Annales pharmaceutiques françaises. 2013 Jun 17 Partner 6
Evidence of endogenous volatile organic compounds as biomarkers of diseases in alveolar breath.
C. Sarbach, P. Stevens, J. Whiting, P. Puget, M. Humbert, S. Cohen-Kaminsky, E. Postaire
Link

Int J Pharm. 2013 Jun 17 Partner 16
Protein entrapment in PEGylated lipid nanoparticles.
Angelina Angelova, Borislav Angelov, Markus Drechsler, Vasil M. Garamus, Sylviane Lesieur.
Link

Cancer Radiother. 2013 Jun 17. [Epub ahead of print] Partner 8
Risk analysis in radiation therapy: State of the art.
Mazeron R, Aguini N, Deutsch E.
Link

Clin Cancer Res. 2013 Jun 19. [Epub ahead of print] Partner 9
Impact of bioinformatic procedures in the development and translation of high-throughput molecular classifiers in Oncology.
Ferte C, Trister AD, Huang E, Bot BM, Guinney J, Commo F, Sieberts S, Andre F, Besse B, Soria JC, Friend SH.
Link

Clin Lung Cancer. 2013 Jun 14. [Epub ahead of print] Partner 9
19q13-ERCC1 Gene Copy Number Increase in Non-Small-Cell Lung Cancer.
Vanhecke E, Valent A, Tang X, Vielh P, Friboulet L, Tang T, Goubar A, Li Y, Robin A, Behrens C, Commo F, Validire P, André F, Wistuba II, Soria JC, Olaussen KA.
Link

Eur J Pharm & Biopharm. 2013 Jun 18 Partner 16
Hyaluronic acid-coated liposomes for active targeting of gemcitabine.
Silvia Arpicco, Carlotta Lerda, Elisa Dalla Pozza, Chiara Costanzo, Nicolas Tsapis, Barbara Stella, Massimo Donadelli, Ilaria Dando, Elias Fattal, Luigi Cattel, Marta Palmieri
Link

Diagnostic Microbiology and Infectious Disease. 2013 Jun 18 Partner 7
Probe ligation and real-time detection of KPC, OXA-48, VIM, IMP, and NDM carbapenemase genes.
G. Cuzon, T. Naas, P. Bogaerts, Y. Glupczynski, P. Nordmann
Link

MAY

The signal peptide of the tumor-shared antigen midkine hosts CD4+ T cell epitopes.
Kerzerho J, Schneider A, Favry E, Castelli FA, Maillère B.
J Biol Chem. 2013 May 10;288(19):13370-7. Partner 11

Combination of vascular disrupting agents and ionizing radiation.
Clémenson C, Chargari C, Deutsch E.
Crit Rev Oncol Hematol. 2013 May;86(2):143-60. Review. Partner 8

Epac in cardiac calcium signaling.
Ruiz-Hurtado G, Morel E, Domínguez-Rodríguez A, Llach A, Lezoualc'h F, Benitah JP, Gomez AM.
J Mol Cell Cardiol. 2013 May;58:162-71. Review. Partner 1

Mol Cancer Ther. 2013 May 2. [Epub ahead of print] Partner 8
IGF-1R targeting increases the antitumor effects of DNA damaging agents in SCLC model: an opportunity to increase the efficacy of standard therapy.
Ferte C, Loriot Y, Clemenson C, Commo F, Gombos A, Bibault JE, Fumagalli I, Hamama S, Auger N, Lahon B, Chargari C, Calderaro J, Soria JC, Deutsch E.
Link

J Immunol. 2013 May 1. [Epub ahead of print] Partner 11
Hierarchy of CD4 T Cell Epitopes of the ANRS Lipo5 Synthetic Vaccine Relies on the Frequencies of Pre-Existing Peptide-Specific T Cells in Healthy Donors.
Castelli FA, Szely N, Olivain A, Casartelli N, Grygar C, Schneider A, Besse A, Levy Y, Schwartz O, Maillère B.
Link

Clin Cancer Res. 2013 May 8. [Epub ahead of print] Partner 9
Targeting FGFR With Dovitinib (TKI258): Preclinical and Clinical Data in Breast Cancer.
Andre F, Bachelot T, Campone M, Dalenc F, Perez-Garcia J, Hurvitz SA, Turner NC, Rugo H, Smith JW, Deudon S, Shi MM, Zhang Y, Kay A, Graus Porta D, Yovine A, Baselga J.
Link

Langmuir. 2013 May 6. [Epub ahead of print] Partner 16
Quatsomes: vesicles formed by self-assembly of sterols and quaternary ammonium surfactants.
Ferrer-Tasies L, Moreno-Calvo E, Cano M, Aguilella-Arzo M, Angelova A, Lesieur S, Ricart S, Faraudo J, Ventosa N, Veciana J.
Link

Int J Antimicrob Agents. 2013 May 8. [Epub ahead of print] Partner 7
Dissemination of the KPC-2 carbapenemase in non-Klebsiella pneumoniae enterobacterial isolates from Colombia.
Cuzon G, Naas T, Correa A, Quinn JP, Villegas MV, Nordmann P.
Link

Eur Heart J Cardiovasc Imaging. 2013 May 15. [Epub ahead of print] Partner 6
Non-invasive indices of right ventricular function are markers of ventricular-arterial coupling rather than ventricular contractility: insights from a porcine model of chronic pressure overload.
Guihaire J, Haddad F, Boulate D, Decante B, Denault AY, Wu J, Hervé P, Humbert M, Dartevelle P, Verhoye JP, Mercier O, Fadel E.
Link

Thromb Haemost. 2013 May 16;110(1). [Epub ahead of print] Partner 6
Factors associated with diagnosis and operability of chronic thromboembolic pulmonary hypertension. A case-control study.
Lang IM, Simonneau G, Pepke-Zaba JW, Mayer E, Ambrož D, Blanco I, Torbicki A, Mellemkjaer S, Yaici A, Delcroix M.
Link

Front Physiol. 2013 May 10;4:102. Partner 2
Mitochondrial dynamics in the adult cardiomyocytes: which roles for a highly specialized cell?
Piquereau J, Caffin F, Novotova M, Lemaire C, Veksler V, Garnier A, Ventura-Clapier R, Joubert F.
Link

Chest. 2013 May 9. [Epub ahead of print] Partner 6
Left ventricular ejection time in acute heart failure complicating pre-capillary pulmonary hypertension.
Sztrymf B, Günther S, Artaud-Macari E, Savale L, Jaïs X, Sitbon O, Simonneau G, Humbert M, Chemla D.
Link

J Clin Oncol. 2013 May 13. [Epub ahead of print] Partner 9
Detection of Circulating Tumor Cells Harboring a Unique ALK Rearrangement in ALK-Positive Non-Small-Cell Lung Cancer.
Pailler E, Adam J, Barthélémy A, Oulhen M, Auger N, Valent A, Borget I, Planchard D, Taylor M, André F, Soria JC, Vielh P, Besse B, Farace F.
Link

Int J Pharm. 2013 May 9. [Epub ahead of print] Partner 16
Molecular weight controls the elongation of oblate-shaped degradable poly(γ-benzyl-l-glutamate)nanoparticles.
Cauchois O, Segura-Sanchez F, Ponchel G.
Link

Nanoscale. 2013 May 15. [Epub ahead of print] Partner 12
Carbon nanotube-gold nanohybrids for selective catalytic oxidation of alcohols.
Rahul Kumar, Edmond Gravel, Agnes Hagege, Haiyan Li, Dhanaji Jawale, Deepti verma, Irishi Namboothiri and Eric Doris
Link

Biochim Biophys Acta. 2013 May 16. [Epub ahead of print] Partner 2
Progressive stages of mitochondrial destruction caused by cell toxic bile salts.
Schulz S, Schmitt S, Wimmer R, Aichler M, Eisenhofer S, Lichtmannegger J, Eberhagen C, Artmann R, Tookos F, Walch A, Krappmann D, Brenner-Jan C, Rust C, Zischka H.
Link

Int J Pharm. 2013 May 21. [Epub ahead of print] Partner 16
Synthesis and in vitro studies of gold nanoparticles loaded with docetaxel.
de Oliveira R, Zhao P, Li N, de Santa Maria LC, Vergnaud J, Ruiz J, Astruc D, Barratt G.
Link

Int J Nanomedicine. 2013;8:2065-76. Epub 2013 May 27. Partner 16
Development of biodegradable methylprednisolone microparticles for treatment of articular pathology using a spray-drying technique.
Tobar-Grande B, Godoy R, Bustos P, von Plessing C, Fattal E, Tsapis N, Olave C, Gómez-Gaete C.
Link

Ann Rheum Dis. 2013 May 30. [Epub ahead of print] Partner 4
Evaluation of low-dose rituximab for the retreatment of patients with active rheumatoid arthritis: a non-inferiority randomised controlled trial.
Mariette X, Rouanet S, Sibilia J, Combe B, Le Loët X, Tebib J, Jourdan R, Dougados M.
Link

PLoS One. 2013 May 24;8(5):e59868. Partner 4
Serum Levels of Beta2-Microglobulin and Free Light Chains of Immunoglobulins Are Associated with Systemic Disease Activity in Primary Sjögren's Syndrome. Data at Enrollment in the Prospective ASSESS Cohort.
Gottenberg JE, Seror R, Miceli-Richard C, Benessiano J, Devauchelle-Pensec V, Dieude P, Dubost JJ, Fauchais AL, Goeb V, Hachulla E, Hatron PY, Larroche C, Le Guern V, Morel J, Perdriger A, Puéchal X, Rist S, Saraux A, Sene D, Sibilia J, Vittecoq O, Nocturne G, Ravaud P, Mariette X.
Link

Chest. 2013 May 1;143(5):1343-50. Partner 6
Estimating right ventricular stroke work and the pulsatile work fraction in pulmonary hypertension.
Chemla D, Castelain V, Zhu K, Papelier Y, Creuzé N, Hoette S, Parent F, Simonneau G, Humbert M, Herve P.
Link

PLoS One. 2013 May 31;8(5):e65090. Partner 6
Temporal Asthma Patterns Using Repeated Questionnaires over 13 Years in a Large French Cohort of Women.
Sanchez M, Bousquet J, Le Moual N, Jacquemin B, Clavel-Chapelon F, Humbert M, Kauffmann F, Tubert-Bitter P, Varraso R.
Link

Eur J Med Chem. 2013 May 10;65C:284-294. [Epub ahead of print] Partner 15
Synthesis of novel guttiferone A derivatives: In-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
Fromentin Y, Gaboriaud-Kolar N, Lenta BN, Wansi JD, Buisson D, Mouray E, Grellier P, Loiseau PM, Lallemand MC, Michel S.
Link

Int J Pharm. 2013 May 31. [Epub ahead of print] Partner 16
Development of oil-in-water microemulsions for the oral delivery of amphotericin B.
Silva AE, Barratt G, Chéron M, Egito ES.
Link

Onkologie. 2013;36(6):357-62. Epub 2013 May 13. Partner 8 & Partner 9
Clinical benefit for patients with non-small cell lung cancer enrolled in phase I trials.
Levy A, Gomez-Roca C, Massard C, Planchard D, Albiges L, Bahleda R, Bourgier C, Deutsch E, Soria JC, Besse B.
Link

APRIL

The vascular disrupting agent ombrabulin (AVE8062) enhances the efficacy of standard therapies in head and neck squamous cell carcinoma xenograft models.
Clémenson C, Jouannot E, Merino-Trigo A, Rubin-Carrez C, Deutsch E.
Invest New Drugs. 2013 Apr;31(2):273-84. Partner 8

Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs.
Rasolofonjatovo E, Provot O, Hamze A, Rodrigo J, Bignon J, Wdzieczak-Bakala J, Lenoir C, Desravines D, Dubois J, Brion JD, Alami M.
Eur J Med Chem. 2013 Apr;62:28-39. Partner 15

Mol Immunol. 2013 Apr;53(4):453-9 Partner 11
Human CD4 T cell epitopes selective for Vaccinia versus Variola virus.
Probst A, Besse A, Favry E, Imbert G, Tanchou V, Castelli FA, Maillere B.
Link

Cancer Res. 2013 Apr 1;73(7):2271-2280. Partner 2
Cisplatin Resistance Associated with PARP Hyperactivation.
Michels J, Vitale I, Galluzzi L, Adam J, Olaussen KA, Kepp O, Senovilla L, Talhaoui I, Guegan J, Enot DP, Talbot M, Robin A, Girard P, Oréar C, Lissa D, Sukkurwala AQ, Garcia P, Behnam-Motlagh P, Kohno K, Wu GS, Brenner C, Dessen P, Saparbaev M, Soria JC, Castedo M, Kroemer G.
Link

Cancer Treat Rev. 2013 Apr 1. pii: S0305-7372(13)00038-8. [Epub ahead of print] Partner 9
mTOR inhibitors in advanced breast cancer: Ready for prime time?
Martin LA, André F, Campone M, Bachelot T, Jerusalem G.
Link

J Biol Chem. 2013 Apr 3. [Epub ahead of print] Partner 11
The signal peptide of the tumor-shared antigen Midkine hosts CD4+ T cell epitopes.
Kerzerho J, Schneider A, Favry E, Castelli FA, Maillère B.
Link

Immunity. 2013 Apr 2. [Epub ahead of print] Partner 3
Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells.
Ma Y, Adjemian S, Mattarollo SR, Yamazaki T, Aymeric L, Yang H, Portela Catani JP, Hannani D, Duret H, Steegh K, Martins I, Schlemmer F, Michaud M, Kepp O, Sukkurwala AQ, Menger L, Vacchelli E, Droin N, Galluzzi L, Krzysiek R, Gordon S, Taylor PR, Van Endert P, Solary E, Smyth MJ, Zitvogel L, Kroemer G.
Link

Org. Biomol. Chem. 2013 [Epub ahead of print] Partner 15
An Efficient Coupling of N-Tosylhydrazones with 2-Halopyridines: Synthesis of 2-alpha-Styrylpyridines Endowed with Antitumor Activity.
Marie Lawson , Abdallah Hamze , Jean-Francois Peyrat , Jerome Bignon , Joelle Dubois , Jean Daniel Brion and Mouad Alami
Link

J Hepatol. 2013 Apr 5. [Epub ahead of print] Partner 2
Decoding cell death signals in liver inflammation.
Brenner C, Galluzzi L, Kepp O, Kroemer G.
Link

J Antimicrob Chemother. 2013 Apr 7. [Epub ahead of print] Partner 7
Complete sequence of two KPC-harbouring plasmids from Pseudomonas aeruginosa.
Naas T, Bonnin RA, Cuzon G, Villegas MV, Nordmann P.
Link

Mol Endocrinol. 2013 Apr 11. [Epub ahead of print] Partner 15
A New Strategy for Selective Targeting of Progesterone Receptor with Passive Antagonists.
Khan JA, Tikad A, Fay M, Hamze A, Fagart J, Chabbert-Buffet N, Meduri G, Amazit L, Brion JD, Alami M, Lombès M, Loosfelt H, Rafestin-Oblin ME.
Link

Chest. 2013 Apr 11.[Epub ahead of print] Partner 6
A proof of concept randomized-controlled trial of omalizumab in patients with severe difficult to control nonatopic asthma.
Garcia G, Magnan A, Chiron R, Contin-Bordes C, Berger P, Taillé C, Devouassoux G, de Blay F, Couderc LJ, Didier A, O'Callaghan DS, Girodet PO, Bourdeix I, Le Gros V, Humbert M.
Link

J Clin Oncol. 2013 Apr 8. [Epub ahead of print] Partner 9
AVEREL: A Randomized Phase III Trial Evaluating Bevacizumab in Combination With Docetaxel and Trastuzumab as First-Line Therapy for HER2-Positive Locally Recurrent/Metastatic Breast Cancer.
Gianni L, Romieu GH, Lichinitser M, Serrano SV, Mansutti M, Pivot X, Mariani P, Andre F, Chan A, Lipatov O, Chan S, Wardley A, Greil R, Moore N, Prot S, Pallaud C, Semiglazov V.
Link

J Struct Biol. 2013 Apr 5. [Epub ahead of print] Partner 11
Crystallization of bi-functional ligand protein complexes.
Antoni C, Vera L, Devel L, Catalani MP, Czarny B, Cassar-Lajeunesse E, Nuti E, Rossello A, Dive V, Stura EA.
Link

Toxicol Sci. 2013 Apr 5. [Epub ahead of print] Partner 3
Allergic Skin Inflammation Induced by Chemical Sensitizers is Controlled by the Transcription Factor NRF2.
El Ali Z, Gerbeix C, Hemon P, Esser PR, Martin SF, Pallardy M, Kerdine-Römer S.
Link

Biomaterials. 2013 Apr 2. [Epub ahead of print] Partner 12 & Partner 16
Anti-HIV efficacy and biodistribution of nucleoside reverse transcriptase inhibitors delivered as squalenoylated prodrug nanoassemblies.
Hillaireau H, Dereuddre-Bosquet N, Skanji R, Bekkara-Aounallah F, Caron J, Lepêtre S, Argote S, Bauduin L, Yousfi R, Rogez-Kreuz C, Desmaële D, Rousseau B, Gref R, Andrieux K, Clayette P, Couvreur P.
Link

J Hepatol. 2013 Apr 9.[Epub ahead of print] Partner 3
Blockade of CCR5 to protect the liver graft in HIV/HCV coinfected patients.
Haïm-Boukobza S, Balabanian K, Teicher E, Bourgeade M, Perlemuter G, Roque-Afonso AM, Duclos-Vallee JC.
Link

Cancer Metastasis Rev. 2013 Apr 18. [Epub ahead of print] Partner 8
Personalized radiation therapy and biomarker-driven treatment strategies: a systematic review.
Bibault JE, Fumagalli I, Ferté C, Chargari C, Soria JC, Deutsch E.
Link

Mar Drugs. 2013 Apr 17;11(4):1304-15. Partner 15
Antimalarial Activity of Axidjiferosides, New β-Galactosylceramides from the African Sponge Axinyssa djiferi.
Farokhi F, Grellier P, Clément M, Roussakis C, Loiseau PM, Genin-Seward E, Kornprobst JM, Barnathan G, Wielgosz-Collin G.
Link

Org Biomol Chem. 2013 Apr 15. [Epub ahead of print] Partner 15
A palladium-catalyzed coupling of 3-chloroquinoxalinones with various nitrogen-containing nucleophiles.
Brachet E, Peyrat JF, Brion JD, Messaoudi S, Alami M.
Link

Int. J. Pharm. 2013 Apr 17. Published on line Partner 16
Formulation of pyrazinamide-loaded large porous particles for the pulmonary route: avoiding crystal growth using excipients.
DD Pham, E Fattal, NE Ghermani, N Guiblin, N Tsapis
Link

J Biol Chem. 2013 Apr 25. [Epub ahead of print] Partner 11
Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121: insights from biochemical studies and crystal structures.
Fonvielle M, Le Du MH, Lequin O, Lecoq A, Jacquet M, Thai R, Dubois S, Grach G, Gondry M, Belin P.
Link

Microb Cell Fact. 2013 Apr 22;12(1):37. [Epub ahead of print] Partner 11
High throughput screening identifies disulfide isomerase DsbC as a very efficient partner for recombinant expression of small disulfide-rich proteins in E. coli.
Nozach H, Fruchart-Gaillard C, Fenaille F, Beau F, Ramos OH, Douzi B, Saez NJ, Moutiez M, Servent D, Gondry M, Thaï R, Cuniasse P, Vincentelli R, Dive V.
Link

J Clin Oncol. 2013 Apr 29. [Epub ahead of print] Partner 9
Next-Generation Sequencing Reveals High Concordance of Recurrent Somatic Alterations Between Primary Tumor and Metastases From Patients With Non-Small-Cell Lung Cancer.
Vignot S, Frampton GM, Soria JC, Yelensky R, Commo F, Brambilla C, Palmer G, Moro-Sibilot D, Ross JS, Cronin MT, André F, Stephens PJ, Lazar V, Miller VA, Brambilla E.
Link

Org Biomol Chem. 2013 Apr 24. [Epub ahead of print] Partner 15
An efficient coupling of N-tosylhydrazones with 2-halopyridines: synthesis of 2-α-styrylpyridines endowed with antitumor activity.
Lawson M, Hamze A, Peyrat JF, Bignon J, Dubois J, Brion JD, Alami M.
Link

Sci. Signal., 30 April 2013 Vol. 6, Issue 273, p. ra30 Partner 3
β-Arrestin–Dependent Activation of the Cofilin Pathway Is Required for the Scavenging Activity of the Atypical Chemokine Receptor D6.
Elena M. Borroni, Cinzia Cancellieri, Alessandro Vacchini, Yann Benureau, Bernard Lagane, Françoise Bachelerie, Fernando Arenzana-Seisdedos, Kensaku Mizuno, Alberto Mantovani, Raffaella Bonecchi, and Massimo Locati
Link

Acta Crystallogr B Struct Sci Cryst Eng Mater. 2013 Apr 1;69(Pt 2):214-27. Partner 16
A highly hydrated α-cyclodextrin/1-undecanol inclusion complex: crystal structure and hydrogen-bond network from high-resolution neutron diffraction at 20 K.
Gallois-Montbrun D, Le Bas G, Mason SA, Prangé T, Lesieur S.
Link

MARCH

Carbonic anhydrase binding site parameterization in OPLS-AA force field.
Bernadat G, Supuran CT, Iorga BI.
Bioorg Med Chem. 2013 Mar 15;21(6):1427-30. Partner 13&15

Catalytic enantioselective vinylogous Mukaiyama-Michael addition of 2-silyloxyfurans to cyclic unsaturated oxo esters.
Jusseau X, Retailleau P, Chabaud L, Guillou C.
J Org Chem. 2013 Mar 15;78(6):2289-300. Partner 13

Cardiovasc Res. 2013 Mar 8. [Epub ahead of print] Partner 2
An SRF/miR-1 axis regulates NCX1 and Annexin A5 protein levels in the normal and failing heart.
Tritsch E, Mallat Y, Lefebvre F, Diguet N, Escoubet B, Blanc J, De Windt L, Catalucci D, Vandecasteele G, Li Z, Mericskay M.
Link

Cardiovasc Res. 2013 Mar 1. [Epub ahead of print] Partner 2
ROS Regulation of Microdomain Ca2+ Signaling at the Dyads.
Zhang H, Gomez AM, Wang X, Yan Y, Zheng M, Cheng H.
Link

Molecules. 2013 Mar 6;18(3):3018-27. Partner 13
Natural Aristolactams and Aporphine Alkaloids as Inhibitors of CDK1/Cyclin B and DYRK1A.
Marti G, Eparvier V, Morleo B, Ven JL, Apel C, Bodo B, Amand S, Dumontet V, Lozach O, Meijer L, Guéritte F, Litaudon M.
Link

Lancet Oncol. 2013 Mar;14(3):191-2. Partner 9
What can be done for patients with NSCLC without druggable targets?
Besse B, Andre F, Soria JC.
Link

Eur J Immunol. 2013 Mar 20. [Epub ahead of print] Partner 3
S1PR5 is pivotal for the homeostasis of patrolling monocytes.
Debien E, Mayol K, Biajoux V, Daussy C, De Aguero MG, Taillardet M, Dagany N, Brinza L, Henry T, Dubois B, Kaiserlian D, Marvel J, Balabanian K, Walzer T.
Link

Anal Chem. 2013 Mar 18. [Epub ahead of print] Partner 15
Solid State Electrochemical Assay of Heme-Binding Molecules for Screening of Drugs with Antimalarial Potential.
Doménech-Carbó A, Maciuk AR, Figadere B, Poupon E, Cebrián-Torrejón G.
Link

J Med Chem. 2013 Mar 21. [Epub ahead of print] Partner 11 & Partner 12
N-methyl dihydroquinazolinones derivatives of Retro-2 with enhanced efficacy against Shiga toxin.
Noel R, Gupta N, Pons V, Goudet A, Garcia-Castillo MD, Michau A, Martinez J, Buisson DA, Johannes L, Gillet D, Barbier J, Cintrat JC.
Link

N Engl J Med. 2013 Mar 21;368(12):1101-10. Partner 9
ERCC1 isoform expression and DNA repair in non-small-cell lung cancer.
Friboulet L, Olaussen KA, Pignon JP, Shepherd FA, Tsao MS, Graziano S, Kratzke R, Douillard JY, Seymour L, Pirker R, Filipits M, André F, Solary E, Ponsonnailles F, Robin A, Stoclin A, Dorvault N, Commo F, Adam J, Vanhecke E, Saulnier P, Thomale J, Le Chevalier T, Dunant A, Rousseau V, Le Teuff G, Brambilla E, Soria JC.
Link

Nat Genet. 2013 Mar 17. [Epub ahead of print] Partner 6
Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension.
Germain M, Eyries M, Montani D, Poirier O, Girerd B, Dorfmüller P, Coulet F, Nadaud S, Maugenre S, Guignabert C, Carpentier W, Vonk-Noordegraaf A, Lévy M, Chaouat A, Lambert JC, Bertrand M, Dupuy AM, Letenneur L, Lathrop M, Amouyel P, de Ravel TJ, Delcroix M, Austin ED, Robbins IM, Hemnes AR, Loyd JE, Berman-Rosenzweig E, Barst RJ, Chung WK, Simonneau G, Trégouët DA, Humbert M, Soubrier F.
Link

Int J Pharm. 2013 Mar 7. pii: S0378-5173(13)00208-1. [Epub ahead of print] Partner 16
Note on the Formulation of Thermosensitive and Mucoadhesive Vaginal Hydrogels Containing the miniCD4 M48U1 as Anti-HIV-1 Microbicide.
Bouchemal K, Frelichowska J, Martin L, Moal VL, Le Grand R, Bosquet N, Djabourov M, Aka-Any-Grah A, Koffi A, Ponchel G.
Link

Cell Cycle. 2013 Mar 15;12(6):877-83. Epub 2013 Feb 21. Partner 2
Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer.
Michels J, Vitale I, Senovilla L, Enot DP, Garcia P, Lissa D, Olaussen KA, Brenner C, Soria JC, Castedo M, Kroemer G.
Link

Toxicol Sci. 2013 Mar 27. [Epub ahead of print] Partner 3
Reactivity of chemical sensitizers toward amino acids in cellulo plays a role in the activation of the Nrf2-ARE pathway in human monocyte dendritic cells and the THP-1 cell line.
Migdal C, Botton J, El Ali Z, Azoury ME, Guldemann J, Giménez-Arnau E, Lepoittevin JP, Kerdine-Römer S, Pallardy M.
Link

J Drug Deliv. 2013;2013:860780. Epub 2013 Mar 7. Partner 16
Lipid-Based Nanovectors for Targeting of CD44-Overexpressing Tumor Cells.
Arpicco S, De Rosa G, Fattal E.
Link

PLoS Genet. 2013 Mar;9(3):e1003400. Epub 2013 Mar 28. Partner 5
Differential Evolutionary Fate of an Ancestral Primate Endogenous Retrovirus Envelope Gene, the EnvV Syncytin, Captured for a Function in Placentation.
Esnault C, Cornelis G, Heidmann O, Heidmann T.
Link

PLoS Genet. 2013 Mar;9(3):e1003394. Epub 2013 Mar 28. Partner 4
Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis.
Cui J, Stahl EA, Saevarsdottir S, Miceli C, Diogo D, Trynka G, Raj T, Mirkov MU, Canhao H, Ikari K, Terao C, Okada Y, Wedrén S, Askling J, Yamanaka H, Momohara S, Taniguchi A, Ohmura K, Matsuda F, Mimori T, Gupta N, Kuchroo M, Morgan AW, Isaacs JD, Wilson AG, Hyrich KL, Herenius M, Doorenspleet ME, Tak PP, Crusius JB, van der Horst-Bruinsma IE, Wolbink GJ, van Riel PL, van de Laar M, Guchelaar HJ, Shadick NA, Allaart CF, Huizinga TW, Toes RE, Kimberly RP, Bridges SL Jr, Criswell LA, Moreland LW, Fonseca JE, de Vries N, Stranger BE, De Jager PL, Raychaudhuri S, Weinblatt ME, Gregersen PK, Mariette X, Barton A, Padyukov L, Coenen MJ, Karlson EW, Plenge RM.
Link

Org Lett. 2013 Mar 29. [Epub ahead of print] Partner 13
Iodine(III)-Mediated Umpolung of Bromide Salts for the Ethoxybromination of Enamides.
Nocquet-Thibault S, Retailleau P, Cariou K, Dodd RH.
Link

Bioorg Med Chem Lett. 2013 Mar 20.[Epub ahead of print] Partner 11
Identification of new peptide amides as selective cathepsin L inhibitors: The first step towards selective irreversible inhibitors?
Torkar A, Lenarčič B, Lah T, Dive V, Devel L.
Link

FEBRUARY

From molecular to nanotechnology strategies for delivery of neurotrophins: emphasis on brain-derived neurotrophic factor (BDNF).
Géral C, Angelova A, Lesieur S.
Pharmaceutics. 2013 Feb 8;5(1):127-67. Partner 16

Drug Dev Ind Pharm. 2013 Feb;39(2):310-20 Partner 16
Successful factorial design for the optimization of methylprednisolone encapsulation in biodegradable nanoparticles.
Gómez-Gaete C, Bustos GL, Godoy RR, Saez CK, Novoa GP, Fernández EM, Tsapis N, Fattal E.
Link

J Comput Chem. 2013 Feb 5. [Epub ahead of print] Partner 11
A multiscale coarse-grained polarisable solvent model for handling long tail bulk electrostatics.
Masella M, Borgis D, Cuniasse P.
Link

Biochim Biophys Acta. 2013 Feb 2. [Epub ahead of print] Partner 16
Targeting gemcitabine containing liposomes to CD44 expressing pancreatic adenocarcinoma cells causes an increase in the antitumoral activity.
Pozza ED, Lerda C, Costanzo C, Donadelli M, Dando I, Zoratti E, Scupoli MT, Beghelli S, Scarpa A, Fattal E, Arpicco S, Palmieri M.
Link

J Nat Prod. 2013 Feb 6. [Epub ahead of print] Partner 13
Isolation and Characterization of Unusual Hydrazides from Streptomyces sp. Impact of the Cultivation Support and Extraction Procedure.
Le Goff G, Martin MT, Iorga BI, Adelin E, Servy C, Cortial S, Ouazzani J.
Link

Biomacromolecules. 2013 Feb 6. [Epub ahead of print] Partner 16
Drug-Induced Nanocarrier Assembly as a Strategy for the Cellular Delivery of Nucleotides and Nucleotide Analogues.
Giacalone G, Bochot A, Fattal E, Hillaireau H.
Link

Medicine (Baltimore). 2013 Feb 20. [Epub ahead of print] Partner 4
The Spectrum of Type I Cryoglobulinemia Vasculitis: New Insights Based on 64 Cases.
Terrier B, Karras A, Kahn JE, Guenno GL, Marie I, Benarous L, Lacraz A, Diot E, Hermine O, de Saint-Martin L, Cathébras P, Leblond V, Modiano P, Léger JM, Mariette X, Senet P, Plaisier E, Saadoun D, Cacoub P.
Link

Cancer Discov. 2013 Feb 15. [Epub ahead of print] Partner 9
Fibroblast Growth Factor Receptor Inhibitors as a Cancer Treatment: From a Biologic Rationale to Medical Perspectives.
Dieci MV, Arnedos M, Andre F, Soria JC.
Link

J Immunol. 2013 Mar 1;190(5):1895. Partner 11
Comment on "the role of naive T cell precursor frequency and recruitment in dictating immune response magnitude".
Maillere B.
Link

Lung Cancer. 2013 Feb 11. [Epub ahead of print] Partner 9
PARP1 impact on DNA repair of platinum adducts: Preclinical and clinical read-outs.
Olaussen KA, Adam J, Vanhecke E, Vielh P, Pirker R, Friboulet L, Popper H, Robin A, Commo F, Thomale J, Kayitalire L, Filipits M, Le Chevalier T, André F, Brambilla E, Soria JC.
Link

J Org Chem. 2013 Feb 14. [Epub ahead of print] Partner 13
Catalytic Enantioselective Vinylogous Mukaiyama-Michael Addition of 2-Silyloxyfurans to Cyclic Unsaturated Oxo Esters.
Jusseau X, Retailleau P, Chabaud L, Guillou C.
Link

Breast Cancer Res Treat. 2013 Feb 14. [Epub ahead of print] Partner 9
Landscape and evolution of therapeutic research for breast cancer patients.
Dogan S, Dieci MV, Goubar A, Arnedos M, Delaloge S, Andre F.
Link

Circulation. 2013 Feb 12. [Epub ahead of print] Partner 6
Imatinib Mesylate as Add-On Therapy for Pulmonary Arterial Hypertension: Results of the Randomized IMPRES Study.
Hoeper MM, Barst RJ, Bourge RC, Feldman J, Frost AE, Galié N, Gómez-Sánchez MA, Grimminger F, Grünig E, Hassoun PM, Morrell NW, Peacock AJ, Satoh T, Simonneau G, Tapson VF, Torres F, Lawrence D, Quinn DA, Ghofrani HA.
Link

Proc Natl Acad Sci U S A. 2013 Feb 11. [Epub ahead of print] Partner 5
Captured retroviral envelope syncytin gene associated with the unique placental structure of higher ruminants.
Cornelis G, Heidmann O, Degrelle SA, Vernochet C, Lavialle C, Letzelter C, Bernard-Stoecklin S, Hassanin A, Mulot B, Guillomot M, Hue I, Heidmann T, Dupressoir A.
Link

Arthritis Care Res (Hoboken). 2013 Feb 11. [Epub ahead of print] Partner 4
Potential classification criteria for rheumatoid arthritis after two years: Results from a French multicenter cohort.
Saraux A, Tobón GJ, Benhamou M, Devauchelle-Pensec V, Dougados M, Mariette X, Berenbaum F, Chiocchia G, Rat AC, Schaeverbeke T, Rincheval N, Fautrel B, Combe B.
Link

Eur Respir J. 2013 Feb 8. [Epub ahead of print] Partner 6
Chronic Thromboembolic Pulmonary Hypertension: Role of medical therapy.
Pepke-Zaba J, Jansa P, Kim NH, Naejie R, Simonneau G.
Link

Cancer Res. 2013 Feb 8. [Epub ahead of print] Partner 9
ATIP3, a novel prognostic marker of breast cancer patient survival, limits cancer cell migration and slows metastatic progression by regulating microtubule dynamics.
Molina A, Velot L, Ghouinem L, Abdelkarim M, Bouchet BP, Luissint AC, Bouhlel I, Morel M, Sapharikas E, di Tommaso A, Honore S, Braguer D, Gruel N, Vincent-Salomon A, Delattre O, Sigal-Zafrani B, Andre F, Terris B, Akhmanova A, Di Benedetto M, Nahmias C, Rodrigues-Ferreira S.
Link

Nucleic Acids Res. 2013 Feb 8. [Epub ahead of print] Partner 11 and Partner 12
The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides.
Ming X, Carver K, Fisher M, Noel R, Cintrat JC, Gillet D, Barbier J, Cao C, Bauman J, Juliano RL.
Link

PLoS One. 2013;8(2):e57052. Epub 2013 Feb 22. Partner 2 and Partner 8
Enhanced Sensitivity to Low Dose Irradiation of ApoE-/- Mice Mediated by Early Pro-Inflammatory Profile and Delayed Activation of the TGFβ1 Cascade Involved in Fibrogenesis
Monceau V, Meziani L, Strup-Perrot C, Morel E, Schmidt M, Haagen J, Escoubet B, Dörr W, Vozenin MC.
Link

Drug Resist Updat. 2013 Feb 19. Partner 8
Understanding the functions of tumor stroma in resistance to ionizing radiation: Emerging targets for pharmacological modulation.
Chargari C, Clemenson C, Martins I, Perfettini JL, Deutsch E.
Link

Eur J Med Chem. 2013 Feb 9;62C:722-727. Partner 12
Synthesis, evaluation and absolute configuration assignment of novel dihydropyrimidin-2-ones as picomolar sodium iodide symporter inhibitors.
Lacotte P, Buisson DA, Ambroise Y.
Link

Biochim Biophys Acta. 2013 Feb 25. Partner 2
Hsp90 inhibition by PU-H71 induces apoptosis through endoplasmic reticulum stress and mitochondrial pathway in cancer cells and overcomes the resistance conferred by Bcl-2.
Gallerne C, Prola A, Lemaire C.
Link

Cancer Res. 2013 Feb 22. [Epub ahead of print] Partner 9
Epithelial-to-mesenchymal transition and autophagy induction in breast carcinoma promote escape from T cell-mediated lysis.
Akalay I, Janji B, Hasmim M, Noman MZ, Andre F, De Cremoux P, Bertheau P, Badoual C, Vielh P, Larsen AK, Sabbah M, Tan TZ, Herr Keira J, Tsang Ying Hung N, Thiery JP, Mami-Chouaib F, Chouaib S.
Link

Arthritis Care Res(Hoboken). 2013 Feb 22. [Epub ahead of print] Partner 4
ESSDAI and ESSPRI: EULAR indexes for a complete picture of primary Sjögren's syndrome patients.
Seror R, Gottenberg JE, Devauchelle-Pensec V, Dubost JJ, Le Guern V, Hayem G, Fauchais AL, Goeb V, Hachulla E, Hatron PY, Larroche C, Morel J, Pedriger A, Puéchal X, Rist S, Saraux A, Sene D, Sibilia J, Vittecoq O, Zarnitsky C, Labetoulle M, Ravaud P, Mariette X.
Link

Nat Struct Mol Biol. 2013 Feb 24. [Epub ahead of print] Partner 11
Structure of the MutLα C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease site.
Gueneau E, Dherin C, Legrand P, Tellier-Lebegue C, Gilquin B, Bonnesoeur P, Londino F, Quemener C, Le Du MH, Márquez JA, Moutiez M, Gondry M, Boiteux S, Charbonnier JB.
Link

BMC Cancer. 2013 Feb 22;13(1):84. Partner 8
Adaptive and innovative Radiation Treatment FOR improving Cancer treatment outcomE(ARTFORCE); a randomized controlled phase II trial for individualized treatment of head and neck cancer.
Heukelom J, Hamming O, Bartelink H, Hoebers F, Giralt J, Herlestam T, Verheij M, Brekel M, Vogel W, Slevin N, Deutsch E, Sonke JJ, Lambin P, Rasch C.
Link

JANUARY

Synthesis of ortho/ortho'-substituted 1,1-diarylethylenes through cross-coupling reactions of sterically encumbered hydrazones and aryl halides.
Roche M, Hamze A, Provot O, Brion JD, Alami M.
J Org Chem. 2013 Jan 18;78(2):445-54. Partner 15

Real-time PCR for detection of blaOXA-48 genes from stools.
Naas T, Cotellon G, Ergani A, Nordmann P.
J Antimicrob Chemother. 2013 Jan;68(1):101-4 Partner 5
Free Article

Synthesis, biological evaluation, and structure-activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors.
Aziz J, Brachet E, Hamze A, Peyrat JF, Bernadat G, Morvan E, Bignon J, Wdzieczak-Bakala J, Desravines D, Dubois J, Tueni M, Yassine A, Brion JD, Alami M.
Org Biomol Chem. 2013 Jan 21;11(3):430-42 Partner 15

Chembiochem. 2013 Jan 2;14(1):107-14 Partner 11
A pan photoaffinity probe for detecting active forms of matrix metalloproteinases.
Nury C, Czarny B, Cassar-Lajeunesse E, Georgiadis D, Bregant S, Dive V.
Link

ChemMedChem. 2013 Jan;8(1):104-11 Partner 12
Synthesis and Evaluation of 3,4-Dihydropyrimidin-2(1H)-ones as Sodium Iodide Symporter Inhibitors.
Lacotte P, Puente C, Ambroise Y.
Link

Eur Respir J. 2013 Jan;41(1):8-9 Partner 6
Chronic thromboembolic pulmonary hypertension: advances from bench to patient management.
Pepke-Zaba J, Hoeper MM, Humbert M.
Link

Drug Discov Today. 2013 Jan;18(1-2):25-34 Partner 16
Oral delivery of anticancer drugs I: general considerations.
Mazzaferro S, Bouchemal K, Ponchel G.
Link

Drug Discov Today. 2013 Jan;18(1-2):93-8 Partner 16
Oral delivery of anticancer drugs II: the prodrug strategy.
Mazzaferro S, Bouchemal K, Ponchel G.
Link

Drug Discov Today. 2013 Jan;18(1-2):99-104 Partner 16
Oral delivery of anticancer drugs III: formulation using drug delivery systems.
Mazzaferro S, Bouchemal K, Ponchel G.
Link

Eur J Cancer. 2013 Jan;49(2):411-5 Partner 4
Dissociated responses to newer antimyeloma drugs identify a subset of refractory patients with an extremely poor prognosis.
Crickx E, Wittnebel S, Pasquier F, Danu A, Bourhis JH, Ribrag V, Boué F, Miceli C, Mariette X, Moreau P, Botton Sd, Ghez D.
Link

J Antimicrob Chemother. 2013 Jan;68(1):101-4 Partner 7
Real-time PCR for detection of blaOXA-48 genes from stools.
Naas T, Cotellon G, Ergani A, Nordmann P.
Link

Curr Opin Oncol. 2013 Jan;25(1):59-65 Partner 10
Lessons From Tumor Reversion For Cancer Treatment.
Amson R, Karp Je, Telerman A.
Link

Ann Oncol. 2013 Jan;24(1):38-46 Partner 8
Controversies and challenges regarding the impact of radiation therapy on survival.
Chargari C, Soria JC, Deutsch E.
Link

PLoS One. 2013;8(1):e53321. Epub 2013 Jan 3. Partner 2
Abnormal Ca(2+) Spark/STOC Coupling in Cerebral Artery Smooth Muscle Cells of Obese Type 2 Diabetic Mice.
Rueda A, Fernández-Velasco M, Benitah JP, Gómez AM.
Link

Eur Cytokine Netw. 2013 Jan 9. [Epub ahead of print] Partner 4
Methylation profile of the promoter region of IRF5 in primary Sjögren's syndrome.
Gestermann N, Koutero M, Belkhir R, Tost J, Mariette X, Miceli-Richard C.
Link

Eur Respir J. 2013 Jan;41(1):3-4. Partner 6
Key roles of Src family tyrosine kinases in the integrity of the pulmonary vascular bed.
Guignabert C, Montani D.
Link

Hepatology. 2013 Jan;57(1):93-102. Partner 2
Glycogen synthase kinase 3-mediated voltage-dependent anion channel phosphorylation controls outer mitochondrial membrane permeability during lipid accumulation.
Martel C, Allouche M, Esposti DD, Fanelli E, Boursier C, Henry C, Chopineau J, Calamita G, Kroemer G, Lemoine A, Brenner C.
Link

Trends Cell Biol. 23, 37-46 Partner 10
TPT1/ TCTP-regulated pathways in phenotypic reprogramming.
Amson, R., Pece, S., Marine, J. C., Fiore, P. P., & Telerman, A.
Link

Antioxid Redox Signal. 2013 Jan 1;18(1):66-79. Partner 3
Nuclear factor erythroid 2-related factor 2 nuclear translocation induces myofibroblastic dedifferentiation in idiopathic pulmonary fibrosis.
Artaud-Macari E, Goven D, Brayer S, Hamimi A, Besnard V, Marchal-Somme J, Ali ZE, Crestani B, Kerdine-Römer S, Boutten A, Bonay M.
Link

Eur J Cancer. 2013 Jan 9 Partner 8
Low- and high-grade esthesioneuroblastomas display a distinct natural history and outcome.
Malouf GG, Casiraghi O, Deutsch E, Guigay J, Temam S, Bourhis J.
Link

Eur J Cancer. 2013 Jan 8. [Epub ahead of print] Partner 8
Targeted therapy-induced radiation recall.
Levy A, Hollebecque A, Bourgier C, Loriot Y, Guigay J, Robert C, Delaloge S, Bahleda R, Massard C, Soria JC, Deutsch E.
Link

Am J Surg. 2013 Jan 9. [Epub ahead of print] Partner 9
Outcome in breast molecular subtypes according to nodal status and surgical procedures.
Mazouni C, Rimareix F, Mathieu MC, Uzan C, Bourgier C, André F, Delaloge S, Garbay JR.
Link

J Med Chem. 2013 Jan 23. [Epub ahead of print] Partner 11
Molecular determinants of a selective matrix metalloprotease-12 inhibitor: Insights from crystallography and thermodynamic studies.
Czarny B, Stura EA, Devel L, Vera L, Lajeunesse E, Beau F, Calderone V, Fragai M, Luchinat C, Dive V.
Link

Ann Oncol. 2013 Jan 20. [Epub ahead of print] Partner 9
Utility of prognostic genomic tests in breast cancer practice: The IMPAKT 2012 Working Group Consensus Statement.
Azim HA Jr, Michiels S, Zagouri F, Delaloge S, Filipits M, Namer M, Neven P, Symmans WF, Thompson A, André F, Loi S, Swanton C.
Link

PLoS One. 2013;8(1):e55660. Epub 2013 Jan 31. Partner 2
Over-expressing mitofusin-2 in healthy mature Mammalian skeletal muscle does not alter mitochondrial bioenergetics.
Lally JS, Herbst EA, Matravadia S, Maher AC, Perry CG, Ventura-Clapier R, Holloway GP.
Link

Eur J Med Chem. 2013 Jan 4;62C:28-39 Partner 15
Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs.
Rasolofonjatovo E, Provot O, Hamze A, Rodrigo J, Bignon J, Wdzieczak-Bakala J, Lenoir C, Desravines D, Dubois J, Brion JD, Alami M
Link

Cancer Res. 2013 Jan 28. [Epub ahead of print] Partner 9
Targeting the deregulated spliceosome core machinery in cancer cells triggers mTOR blockade and autophagy.
Quidville V, Alsafadi S, Goubar A, Commo F, Scott V, Durieu C, Girault I, Baconnais S, Lecam E, Lazar V, Delaloge S, Saghatchian M, Pautier P, Morice P, Dessen P, Vagner S, Andre F.
Link

Nanoscale. 2013 Jan 29. [Epub ahead of print] Partner 12
Cellular uptake and trafficking of polydiacetylene micelles.
Gravel E, Thézé B, Jacques I, Anilkumar P, Gombert K, Ducongé F, Doris E.
Link

Colloids Surf B Biointerfaces. 2013 Jan 29;106C:224-233 Partner 16
Interactions of antileishmanial drugs with monolayers of lipids used in the development of amphotericin B-miltefosine-loaded nanocochleates.
Pham TT, Barratt G, Michel JP, Loiseau PM, Saint-Pierre-Chazalet M.
Link

Am J Respir Crit Care Med. 2013 Jan 1;187(1):14-9. Partner 6
Neurohormonal axis in patients with pulmonary arterial hypertension: friend or foe?
de Man FS, Handoko ML, Guignabert C, Bogaard HJ, Vonk-Noordegraaf A.
Link